Threshold for basophil activation test positivity in neuromuscular blocking agents hypersensitivity reactions
نویسندگان
چکیده
منابع مشابه
Threshold for basophil activation test positivity in neuromuscular blocking agents hypersensitivity reactions
BACKGROUND Several different criteria for the positivity of the flow-assisted Basophil Activation Test (BAT) for the diagnosis of Neuromuscular Blocking Agents (NMBA) hypersensitivity reactions have been used in past studies. Our aims were to determine the threshold for BAT positivity expressed as the stimulation index (SI, calculated as the percentage of activated basophils after stimulation w...
متن کاملThreshold for Positivity and Optimal Dipyrone Concentration in Flow Cytometry-Assisted Basophil Activation Test
PURPOSE Basophil activation occurs both in patients with immediate hypersensitivity reactions to anti-inflammatory drugs and in healthy controls in a dose-dependent manner. Our aims were to define the optimal basophil activation test (BAT) concentration and the threshold for BAT positivity for dipyrone. METHODS From 45 patients with a positive history of an immediate hypersensitivity reaction...
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Methods 83 subjects (66/17 females/males) with reported food adverse reactions were included in the study. Eighteen atopic/allergic subjects were included as controls for the foods to which they had reported no reactions. BAT was performed on heparinazed blood incubated with food extracts. CD63 activation marker was evaluated on basophils by flow-cytometry. The stimulation index (SI) was calcul...
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©International Anesthesia Research Society. Unauthorized Use Prohibited. Almost thirty years ago, residual neuromuscular blockade was documented in a surprisingly high proportion of patients (30%), despite an almost systematic use of anticholinesterase agents.1 Since then, even with the development of shorter-acting neuromuscular blockers, pharmacological reversal, and more widespread use of ne...
متن کاملNeuromuscular Blocking Agents
• Neuromuscular blocking agents are used to improve conditions for tracheal intubation, to provide immobility during surgery, and to facilitate mechanical ventilation. • The main site of action of neuromuscular blocking agents (muscle relaxants) is on the nicotinic cholinergic receptor at the endplate of muscle. They also have effects at presynaptic receptors located on the nerve terminal. • Su...
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ژورنال
عنوان ژورنال: Allergy, Asthma & Clinical Immunology
سال: 2013
ISSN: 1710-1492
DOI: 10.1186/1710-1492-9-42